Medicine "Kontrolok": instructions for use, analogues, reviews
Unfortunately, diseases of the digestive tract, which are associated with impaired normal secretion of hormones, are quite common in modern medicine. Esophagitis, ulcerative lesions of the stomach and intestines are extremely unpleasant and dangerous diseases that require appropriate therapy. Of course, the choice of drugs that can help combat such problems is simply enormous.
Konrolok is considered a rather effective medicine. Instructions for use of the drug is quite simple. According to statistics, this medicine really helps to solve some problems, so doctors often prescribe it to their patients. But what is part of the drug? What properties does it have? Are there any side effects? This information interests many patients.
The composition and form of the drug release
The medicine Kontrolok is available in two forms: tablets and powder for preparing a solution.
In the pharmacy, you can buy white tablets, rounded, with a double shell. The main active ingredient of the drug is pantoprazole, which is present here in the form of sesquihydrate sodium. Today, tablets with a dosage of 20 and 40 mg of pantoprazole are available. Mannitol, anhydrous sodium carbonate, as well as calcium stearate, povidone K90, purified water and crospovidone are used as auxiliary substances in the manufacture.
The tablets are packaged in blisters of 5 or 7 pieces. In one package can be from 1 to 3 such blisters.
Powder for the preparation of the solution is sold in glass bottles. As in the previous case, the main component is pantoprazole sodium sesquihydrate. One vial contains 40 mg of the active substance. In addition, sodium hydroxide and disodium edetate are present in the powder.
About exactly what form of medicine is suitable for your case, your doctor will tell you after a thorough examination.
Basic pharmacological properties
The main active ingredient of the drug is a proton pump inhibitor. This substance affects the parietal cells of the mucous membrane, thereby inhibiting the synthesis of hydrochloric acid in the stomach.
After dissolving in the gastric juice, pantoprazole is transformed into the active form, after which it blocks the final phase of the synthesis of hydrochloric acid. Thus, against the background of therapy, a decrease in gastric acidity is observed, which, in turn, leads to an increase in the amount of gastrin. By the way, if the course of treatment does not last long, the level of gastrin remains within the normal range. Long-term therapy can almost increase the amount of this substance. Only occasionally taking pills provokes active reproduction of the endocrine cells of the stomach, which leads to the development of adenomatoid hyperplasia.
The active components of the drug are rapidly absorbed by the tissues of the gastrointestinal tract. The maximum concentration of the drug in the blood is observed approximately 2 to 2.5 hours after taking the pill. With long-term therapy, pantoprazole levels in the blood become constant.By the way, the bioavailability of the drug does not depend on food intake. The active substance is 98% bound to plasma proteins. Metabolism of the drug occurs in the tissues of the liver. Drug metabolism products are 80% excreted by the kidneys along with urine and 20% along with feces. By the way, compared to other proton pump inhibitors, this drug has greater chemical stability. It is allowed to take even patients with impaired renal function. Metabolites of the drug in the body do not accumulate.
Indications for use of the drug
In what cases it is advisable to take the drug "Kontrolok"? Instructions for use states that this drug is widely used to treat a variety of disorders associated with hypersecretory conditions. Also, the indication for use is Zollinger-Ellison syndrome, reflux esophagitis and the presence of peptic ulcers in the stomach and duodenal tissues.
The tablets "Kontrolok" with a dosage of 20 mg effectively cope with a mild degree of reflux disease. The drug effectively eliminates such unpleasant symptoms as heartburn and sore throat when swallowing.The same form of medication is used for the prevention of gastric ulcer and intestinal ulcers, especially when it comes to patients taking nonsteroidal anti-inflammatory drugs for a long time.
But the tablets with a dosage of 40 mg successfully cope with more severe conditions, including peptic ulcer of the stomach and small intestine, as well as Zollinger-Ellison syndrome. In addition, in conjunction with the anti-bacterial preparations, the Controlok is used to treat lesions caused by the activity of the bacterium Helicobacter pylori. Also, the drug effectively copes with moderate to severe refluxes.
The drug "Kontrolok": instructions for use
Immediately it is worth noting that only a specialist can prescribe this medicine. The dosage and duration of therapy is determined individually, so you should not use the drug "Controlok" (tablets) without permission. Instructions for use is simple, but contains only general recommendations.
As a rule, patients are recommended to take one tablet per day, preferably in the morning, one hour before breakfast. Tablets can not be chewed, dissolve or grind - you need to take a sip completely, drinking plenty of water.With a mild degree of disorder, patients are prescribed a daily dose of 20 mg of the drug. In more severe cases, the initial dose is 40 mg, but after the appearance of improvements, it begins to be gradually reduced.
The duration of therapy also depends on the patient’s condition. For example, in a duodenal ulcer, the drug is taken for two weeks. But with esophagitis, reflux and ulcerative lesions of the stomach, the drug is taken for four weeks.
If we are talking about the treatment of Helicobacter Pylori infection, then the daily dose can be increased to 40-80 mg (one tablet sutra, the second - before dinner). If we are talking about the treatment of severe hypersecretory conditions or Zollinger-Ellison syndrome, then the initial daily dose may be increased to 160 mg of pantoprazole (two tablets in the morning and two in the evening). But this is the maximum amount of the drug and it is gradually starting to be canceled as soon as the first improvements appear.
Intravenous administration of the drug is indicated only if, for one reason or another, tablets cannot be taken. To prepare the solution, the powder in the vial is diluted with a 0.9% sodium chloride solution or 5% glucose solution. The drug is administered slowly over 3-15 minutes.By the way, after preparation, the solution should be used for three hours - after this time it cannot be injected.
If we are talking about the treatment of patients with liver failure, it requires constant monitoring of the level of liver enzymes.
Contraindications to therapy
Many people are interested in information about whether all categories of patients can take the drug "Kontrolok". Instructions for use indicates that this drug has some contraindications, although there are not so many of them. To begin with, it’s worth mentioning the age limit - pills are not prescribed for children under the age of twelve.
In addition, the contraindications include dyspepsia of neurotic origin. A relative limitation is liver failure - if necessary, patients with this diagnosis still take medicine, but under strict medical supervision. Naturally, the drug should not be taken by people suffering from hypersensitivity to any of its components - be sure to read the description of the composition before use.
We should also mention the therapy during pregnancy and lactation. Immediately it should be said that today there is not enough information about the effects of the drug on the child's body. However, doctors do not recommend taking these pills. The decision to conduct such therapy should be made solely by the attending specialist.
Are complications and side effects possible?
Many patients are looking for additional information on whether Controller tablets can be dangerous. The instruction indicates that there is a possibility of some complications during the therapy. On the other hand, in medical practice cases of the development of adverse reactions are recorded extremely rarely - no more than 5% of cases. Nevertheless, it is worth getting acquainted with the list of possible violations.
- In some cases, the drug can cause disorders of the digestive system. For example, patients sometimes complain of nausea, pain in the epigastrium, as well as diarrhea, constipation, and increased gas formation in the intestine.
- In some people, Kontrolok can provoke an allergic reaction.It is accompanied by the appearance of a skin rash, urticaria, itching. Very rarely, on the background of therapy, increased photosensitivity, angioedema, and erythema multiforme, Stephen-Johnson syndrome, Lyell's disease develop.
- Sometimes the drug affects the functioning of the nervous system, which is accompanied by headaches, impaired visual clarity, and dizziness. Very rarely, patients suffer from disorientation, unexplained anxiety, hallucinations and depressive states.
- The drug may cause an increase in liver enzymes. Very rarely, on the background of therapy, hepatocyte damage, development of jaundice, and sometimes liver failure are observed.
- In some patients, there is an increase in body temperature and the appearance of strong peripheral edema. These violations, as a rule, disappear on their own immediately after discontinuation of the drug.
- What other adverse reactions can Controll Control Control cause? Instructions for use suggests that people rarely develop myalgia as well as interstitial nephritis during treatment.
Once again, it is worth noting that side effects are rare and in most cases associated with improper medication. In addition, most complications disappear immediately after discontinuation and do not require any specific therapy. But in any case, when these or other deteriorations appear, it is worth stopping the treatment and contacting your doctor, having told about all the symptoms that have appeared.
Interaction with other drugs
Of course, it is worth trying to find out all the available information before starting therapy with the help of the “Controloc” drug. Instructions for use, analogues, cost and reviews - these are very important points. But you should also read about the possible interaction of these pills with other drugs.
To begin with, it is worth noting that this drug decreases the absorption of those drugs whose bioavailability depends on the level of acidity in the stomach (for example, ketoconazole). And still "Kontrolok" cannot be used along with atazanavir.
In any case, at the reception, be sure to tell your doctor about all the drugs that you are currently taking in order to avoid possible complications.
How much does the medicine cost?
Today, many people are interested in questions about what constitutes the “Controlok” drug. Instructions for use, reviews of the drug, as well as contraindications and possible side effects - this is extremely important information. But for many buyers, the cost of a drug is no less significant.
Immediately it is worth noting that prices will vary depending on the city of your residence, the manufacturer of the drug, the financial policy of the pharmacy, your chosen dosage and number of pills. For example, the cost of one bottle for the preparation of solutions is about 200-300 rubles. A package of 14 tablets with a dosage of 20 mg - 750-800 rubles. But the drug with a dosage of 40 mg is more expensive - the price ranges from 950 to 1200 rubles.
Are there any effective analogues?
Not all patients suitable this drug. Some people have an increased sensitivity, while others simply cannot afford a full course of treatment. What to do in such cases? How to replace the drug "Kontrolok"? Analogs of the drug, of course, exist. And there are funds from different price categories, with a different composition, but the same effect.
The most popular substitute for Kontrolok is Nolpaz and Zolopent.In addition, Pantaz, Proxium, Ulter, as well as Tekta Control, Pantoprazole and Zovan are considered to be quite effective. Any of these remedies can be easily found at any pharmacy.
But you should understand that you can not voluntarily cancel taking the drug "Controlok". Analogs can be prescribed only by the attending physician, so be sure to consult with him about this. The specialist will also help you choose the most effective dosage and determine the duration of the course of treatment.
Kontrolok or Nolpaza: which is better?
As you can see, this drug has a large number of analogues. And today, many patients are interested in the question of what is more effective - Kontrolok or Nolpaz? What better eliminates the symptoms? What is safer for health?
Immediately it is worth noting that "Nolpaz" is a direct analogue, but from another (Slovenian) manufacturer. The main active substance is the same patoprazole. And, according to reviews of patients, these pills also effectively eliminate all the symptoms of gastrointestinal diseases and help to normalize the work of the digestive system.Some doctors argue that during treatment with Nolpaza, the likelihood of side effects is higher. On the other hand, this drug has an undoubted advantage - it is much cheaper. For example, the package "Nolpazy" of 14 tablets with a dose of 20 mg costs only 150-180 rubles. The same number of tablets with a dosage of 40 mg will cost about 300 rubles. Agree, the price difference is palpable. Therefore, many patients choose this drug.
Reviews of patients and doctors
Today, doctors recommend the drug “Controlok” to many patients. Testimonials are another source of valuable information, so readers are primarily interested in the opinions of specialists and those patients who have already undergone treatment.
Doctors mostly speak positively about this drug. Indeed, it helps to eliminate unpleasant symptoms and at the same time gradually normalizes the level of enzymes, thereby eliminating the main cause of the disease. Side effects rarely develop, so medicines can also be called non-hazardous.
What do the patients themselves say about the Kontrolok tablets? The responses of the patients are also mostly positive. Indeed, the course of treatment helps to eliminate a lot of problems.It is convenient to take tablets, and only once a day. Some patients note that the symptoms do not go away immediately after the first pill intake (for example, heartburn remains). This is a normal phenomenon, since the drug has a systemic effect - it does not just neutralize the acidic environment, it normalizes the synthesis of enzymes and hydrochloric acid, but it takes some time.
Some patients note that heartburn, pain in the stomach and other symptoms reappear immediately after discontinuation of the drug. The fact is that this medicine should be stopped drinking gradually, reducing the dose from day to day. Abrupt withdrawal of the drug leads to the same sharp increase in the acidity of gastric juice.
Another disadvantage of the drug is its relatively high cost. Indeed, you can find cheaper counterparts. Nevertheless, it is this German-made medicine that is considered one of the most effective and safe, therefore it is worth the money spent.