"Groprinosin": instructions for use, price, analogues, reviews. Is it possible to give "Groprinosin" to children?
Among infectious human diseases, various viral diseases that occur after viruses enter the human cells and their destructive action are isolated.
It is known that viruses are able to multiply only in living cells, thereby destroying their structure. To combat the insidious pathogens of diseases, immunostimulating and antiviral drugs have been created, which are successfully used by doctors in their practice.
Description of the drug "Groprinosin"
One of these immunostimulating agents with antiviral activity is the drug Groprinosin. Instructions for use contains information on the physico-chemical characteristics of the product.It is produced in the form of round white biconvex tablets with a smooth surface and a risk applied on one side (for better breaking). The active ingredient is inosine pranobex, which is a compound of inosine and a salt formed by the acidic residue of 4-acetamido-benzoic acid and the cationic residue of N, N-dimethylamino-2-propanol. The ratio of salt and inosine is 3: 1. The amount of inosine pranobex in one tablet of the drug "Groprinosin" - 500 mg.
The drug is released in blisters of 10 tablets, which are put in packs, along with instructions for medical use. Packages are 20, 30 and 50 tablets. The average price for 20 tablets is about 500 rubles, for 30 tablets –700 rubles, and for 50 tablets you will have to pay 1,250 rubles.
The main pharmacological action of the drug is to enhance non-specific immunity for a short time and increase interferon synthesis. It is carried out by inosine, and the rest of inosine pranobex allows it to penetrate through the lymphocytic membrane. The drug enhances the biochemical reactions of macrophages, more interleukin is formed, the formation of T-killers and lymphocytes increases.It is a stimulator of free movement and absorption capacity of monocytic, macrophage and neutrophil cells.
An important function of the drug "Groprinosin" is its ability to reduce the formation of the daughter molecules of deoxyribonucleic and ribonucleic acids of viral cells. This is due to the binding of the active ingredient of the drug to the ribosomes of viruses and modification of their stereochemical structure.
The drug reduces the manifestation of symptoms in viral diseases, accelerates the process of resuming the activity of all organs after an infection, increases resistance to viruses.Bioavailability of inosine pranobex is more than 90%, which indicates its rapid and almost complete absorption into the blood. So, if you take this amount of the drug to the dosage of the active substance was 1.5 g, and after 60 minutes to check its concentration in the blood, then the content of inosine pranobex will be 600 μg in 1 ml. If you conduct such an analysis after 120 minutes, this substance is not detected in the blood plasma.
Both compounds of the complex inosine pranobex are rapidly metabolized, and within 24 hours after taking the drug, they fully enter the urine.The inosine residue is modified, like all purine nucleotides, to uric acid, and then its level in the blood increases. Crystals of this acid in the urinary organs can also form.
The 4-acetamido-benzoic acid metabolite is C-O-acyl glucuronide, and the other part of the salt, the N, N-dimethylamino-2-propanol compound, is cleaved to the amine oxide.
Inosine pranobex and its metabolites are not able to accumulate in the body, they are excreted in the composition of urine. Full removal from the body of these substances is carried out after two days.
The drug "Groprinosin" analogues
It is not always possible to find the right drug in the pharmacy. This problem can be solved with the help of similar drugs that have the same or similar active ingredients, but various excipients that do not affect bioavailability. These drugs are made by different manufacturers, respectively, and prices will vary. Thus, the drug "Groprinosin" analogs has similar in structure to the active ingredient. One of these analogues is the drug "Izoprinozin", which also has antiviral effect.Like the drug Groprinosin, its analogues have a dosage of 500 mg of inosine pranobex. Another similar drug is Inosine Pranobex.
Drug "Groprinosin", instructions for use
The drug is used by people with reduced immunity, when viral diseases often torment a person. These can be diseases caused by herpes simplex type 1 viruses, which are localized in the form of small bubbles on the lips or other parts of the face, and of the second type, which are manifested by genital lesions. As an auxiliary component of treatment for such infections, the drug Groprinosin is used. The use of this drug contributes to the rapid healing of the affected areas, prevents the development of new vesicles, erosive ulceration, edema and re-manifestation of the disease.
It is used to treat chronic diseases of the respiratory and urinary organs caused by various viruses, for better recovery of patients after surgery.
The instruction attached to the drug "Groprinosin" (500 mg) also includes indications such as chicken pox, measles, mumps, Epstein-Barr virus, human papilloma virus,subacute sclerosing inflammatory disease of the central nervous system in the form of panencephalitis.
Proven effective use of the drug "Groprinosin" with HPV. When infected with human papillomavirus, pathogens enter the bloodstream, cause in a weakened body the formation of outgrowths in the form of warts, papillomas or condylomas, having a pointed shape on mucous membranes and skin. Some types of virus are oncogenic in nature, capable of causing cervical cancer.Due to the enhancement of non-specific immunity, the use of the drug helps to suppress the multiplication of viruses, which leads to a decrease in the size of the outgrowths or their complete disappearance. And although it is impossible to get rid of the virus completely, but strengthening the immune system will not allow the disease to develop.
Reviews of patients and doctors about the drug
The human body is so individual that the effects of the same medicine on different people can be very different. Therefore, patients taking the drug "Groprinosin", reviews leave both positive and negative. This suggests a diverse effect of the drug on the body.Positive reviews indicate the effectiveness of treatment with Groprinosin. Negative feedback includes possible adverse events.
Among the side effects that may occur, you should highlight the symptoms of dizziness, fatigue, headache, drowsiness, sleep disorders, redness and itching of the skin. The drug may have an effect on the digestive and urinary systems, which manifests itself as poor appetite, nausea, vomiting, stomach pain, indigestion or constipation, and elevated levels of liver enzymes.
After the use of the drug "Groprinosin" reviews can be neutral, when there is no reaction of the body to treatment. In this case, the doctor prescribes a stronger antiviral drug.
How to take the drug
Children and adults with viral diseases prescribe the drug "Groprinosin". Instructions for use indicates taking the medication after meals, the daily dose is divided into 3 or 4 doses. The tablet is washed down with a small volume of water. The daily dose for adults is 50 mg per kg of body weight. The duration of treatment depends on the severity of the viral infection, in most cases it is from 5 to 10 days, with severe infection it is prolonged for another 5 days.
In the treatment of diseases whose pathogens are herpes simplex of the first or second type, the drug is canceled 2 days after the disappearance of the lesions.
Acute forms of viral encephalitis are treated with large doses of the drug "Groprinosin". Instructions for use establish a daily dose of this medication in the amount of 100 mg per kg of body weight. This dose is divided into 6 doses, the duration of treatment is about 10 days. After the course of treatment, the doctor cancels the remedy for 8 days, and then prescribes a repeated course according to the above scheme.
In the treatment of genital warts in combination with their laser removal, the dosage of the drug is 50 mg per kg of weight for 5 days. Then make a break for one month, and so repeated three more times.
How to give children the drug "Groprinosin"
Many parents are faced with such a problem as constant colds in their children, especially if the child began to go to kindergarten. To raise the immunity, doctors advise to drink immunostimulating agents, and often prescribe the drug “Groprinosin” to children. Moms and dads ask a lot of questions to the pediatrician about the use of this medication.Answers to them can be found in the annotation to the drug.
At what age can you give the drug "Groprinosin"? Instructions for children imposes age restrictions. From the age of three it is possible to use this tool. An earlier age is a contraindication.
If it can be used, in what dosage is Groprinosin prescribed? Instructions for children sets the dosage of 50 mg of this drug for each kilogram of body weight. To correctly calculate the daily dose, you need to multiply 50 mg per child's weight. Then divide this dose into 3 or 4 doses. Due to the risks on the surface of the tablet it is convenient to break it in half, if you need a dosage of 250 mg.
Often you can hear negative feedback from parents about Groprinosin. Children do not like the bitter taste of tablets, which is why they refuse to take them. But, having undergone a course of treatment with this drug, children are much less likely to have acute respiratory infections and other viral diseases. And in children suffering from herpes, exacerbations of this disease occur much less.
The Groprinosin tablets are most effective in the early stages of the disease if taken on the first day of onset of symptoms.Due to the low toxicity of the drug, "Groprinosin" is prescribed for older people with heart failure and blood flow disorders.However, under the action of inosine pranobex, with continuous intake, uric acid is produced in greater concentration than the body needs. This is especially observed in older people. Therefore, periodically it is necessary to take blood and urine tests to control its level in biological fluids. With elevated levels of uric acid, the doctor may prescribe the simultaneous use of drugs that reduce its production.
The drug is not contraindicated to the driver of the vehicle and persons serving the moving mechanisms.
Caution should be taken drug "Groprinosin" with drugs that increase uric acid in the blood plasma, for example, allopurinol. This is due to inhibition of xanthine oxidase in the blood. It should not be combined with diuretics such as ethacrynic acid, furosemide, torosemide, as well as drugs that adversely affect renal activity. Since the active component of the drug undergoes transformation in the liver, in case of its diseases it is necessary to limit their intake so as not to overload the organ.
The drug is able to enhance the toxic effect of ethyl alcohol on liver cells, so it is not used with alcohol.
Immunosuppressive drugs have an inhibitory effect on the immunostimulating function of the drug "Groprinosin", which artificially inhibit the body's immunity.
The combination of drugs "Groprinosin" and "Zidovudine" helps to increase the concentration of the active substance in the serum, which slows down its elimination from the body. Therefore, the doctor must adjust the dosage of the drug "Zidovudine" - an antiviral agent used in the composition of the combined antiretroviral treatment.
Who is contraindicated drug
Sometimes there are conditions of the body in which it is impossible to take antiviral and immunostimulatory drugs such as Groprinosin. This drug cannot be used to treat viral diseases in pregnant women and in women who are breastfeeding, because the possibility of its safe use has not been studied and the side effects of the tablets on the fetus or the infant's body have not been established.
Contraindications include gout, urolithiasis and hyperuricemia, in which there is an increased level of uric acid.The use of the drug "Groprinosin" in these diseases will cause an even greater increase in the level of uric acid in the blood, which is completely undesirable.
The drug is contraindicated in diseases of the cardiovascular system, when the frequency, rhythm, the sequence of excitation and contraction of the heart muscle is disturbed.
Some people may be allergic to certain components of the drug when taking Groprinosin.
Do not use the drug in children under 3 years of age, as well as in very thin babies weighing up to 20 kg.
Before prescribing this drug to a patient, the doctor should examine the results of urine and blood tests for the absence of overestimated uric acid, to make sure that there are no symptoms of diseases for which antiviral tablets cannot be taken. Only after this, the doctor will prescribe treatment with Groprinosin.