"Advantan" (cream): instructions and reviews
Allergies are usually accompanied by skin rashes and dermatoses, causing itching and discomfort. To relieve the condition, special topical medications help, among which doctors often prescribe Advantan (cream). Instructions for use, the composition and properties of this tool will be discussed in our article.
This medication can be safely applied to sensitive areas of the skin and even on the face.
The drug "Advantan" - hormonal cream or not? The active substance of the considered agent is methylprednisolone aceponate, which is a local glucocorticosteroid. It binds to cell receptors and suppresses the immune system's response to histamines in the blood, thereby eliminating allergic symptoms. Thus, Advantan Allergy Cream is a hormonal drug, therefore, a dermatologist's consultation is required before its use. This medicine has a predominantly local effect.his blood penetrates so minimally that it can be disregarded with a brief use of Advantan.
Other forms of release
Dosage form of the cream contains a small amount of fat, and the water content, on the contrary, is high, and therefore the use of the drug is recommended for acute or subacute inflammatory process without pronounced soak. The cream eliminates inflammation and on smooth areas of the epidermis, and on its volost part, including skin prone to oily skin.
In addition to the cream, the drug "Advantan" is available in the form of ointment, oily ointment and emulsion.
In the composition of the ointment, the ratio of fat and water is balanced, therefore, it is recommended to be used for inflammatory diseases of the subacute or chronic course of the skin that are not accompanied by weeping. The ointment has a healing effect, eliminating dry skin and restoring its normal fat content.
Oily ointment is an anhydrous dosage form. Indications for its use - long-term chronic inflammatory processes in very dry skin. Due to the occlusal effect, oily ointment has a pronounced therapeutic effect even with strongly pronounced infiltration and lichenification.
Emulsion “Advantan” is applied with a thin layer on the skin, slightly rubbing it. For the treatment of sunburn, this tool is used once or twice a day. If, after applying the emulsion, the skin dry up, you should proceed to the use of the dosage form of the drug with a higher content of fat (ointment or oily ointment).
After application to the skin, all forms of drugs have a local effect, are introduced into the DNA of cells and trigger an active mechanism of action on the dermis of biologically active substances. Under the influence of Advantan, the number of prostaglandins expanding small blood vessels is sharply reduced. At the same time, adrenaline is activated, which has a vasoconstrictor effect. As a result, redness, swelling, itching, pain disappear, that is, inflammation is relieved.
The degree of absorption is influenced by the condition of the skin, the dosage form of the agent used and the method of application (with or without an occlusive dressing). After applying a cream, ointment or oily ointment, the percentage of percutaneous absorption in adults and children with psoriasis and neurodermatitis (atopic dermatitis) was no more than 2.5%, which is only slightly higher compared with healthy volunteers (0.5-1%).
When using the medication in the form of an emulsion, the severity of percutaneous absorption with artificial inflammation was rather low - no more than 0.27%, which is only slightly higher than through healthy dermis (0.17%). When treating the whole body (for example, after sunburn), the systemic dose is about 4 mcg per kilogram of body weight per day (which eliminates the development of systemic effects).
Metabolism and excretion
Hydrolysis of methylprednisalone occurs in the epidermis. The main and most active metabolite is ba-methylprednisolone-17-propionate, which has a higher affinity with corticoid skin recipes, which indicates its bioactivation in the dermis.
After the penetration of ba-methylprednisolone-17-propionate into the systemic circulation, its conjugation with glucuronic acid occurs and inactivation occurs.
The metabolites of methylprednisalone aceponate are derived mainly by the kidneys, the half-life is about sixteen hours. Methylprednisalone aceponon and its metabolites in the body do not accumulate.
Cream "Advantan": the use of the drug
In addition to the above-described active ingredient, the drug contains glycerin, water, alcohol, preservatives and solid fat.The drug "Advantan" (cream or ointment) is used in inflammatory skin diseases that are sensitive to the effects of topical corticosteroids. According to reviews of patients and specialists, this medicine is effective for:
It is also recommended to use the drug for other signs of allergy on the skin, which occur during inflammatory processes in tissues, purulent lesions and blistering.
Cream "Advantan": instructions for use
Apply the drug in a thin layer on the affected area of the skin once a day until a significant improvement occurs. However, continuous daily use of the drug "Advantan" should not last more than twelve weeks. In the case of a significant inflammatory process, it is possible to use an occlusive dressing that will tightly cover the surface of the body from the penetration of fluid and air. The cream in the first two hours evaporates the liquid, eliminates inflammation, cools the surface of the skin, then acts as an ointment.
The drug "Advantan" (cream) is recommended to use according to the following scheme:
Skin with damaged areas thoroughly cleaned with alcohol-free soft antiseptic.
Apply the cream to the epidermis, wait until it is completely absorbed.
The procedure is carried out once a day for three months.
Use of the drug in children
With regard to the use of the drug "Advantan" (cream) for children, the instruction indicates the possibility of its use from four months. The course of treatment should not exceed four weeks.
Side effect of the drug
As a rule, the drug "Advantan" is well tolerated, but in some cases, patients during treatment note the occurrence of undesirable side effects that are associated with intolerance to the main active ingredient - methylprednisolone. They are manifested by itching, burning sensation, erythema, the formation of vesicular rash. If the drug is used for more than four weeks or over an area of more than 10% of the body surface, the following reactions may develop: striae, skin atrophy, telangiectasis, acneform changes of the epidermis, systemic effects that are caused by the absorption of a corticosteroid. Numerous clinical trials have shown that none of the above side effects were observed when using the drug Advantan for up to twelve weeks in adults and up to four weeks in children.
In rare cases, the use of the drug can provoke the occurrence of folliculitis, hypertrichosis, perioral dermatitis, skin depigmentation, an allergic reaction to one of the components of the medicine.
Contraindications to the use of the drug
In certain cases, you can not use the cream "Advantan", instructions for the drug, as a rule, contains such information. The drug is contraindicated to apply when:
skin tuberculosis and skin manifestations of syphilis at the site of application of the drug (corticosteroids cause a decrease in immunity, which can increase the spread of infection);
viral lesions of the epidermis at the site of application of the ointment (the use of GCS in this case can lead to a rapid "spreading" of a viral infection, for example, with herpes recurrent infection, the use of this medication activates the rash, and it will cover all new areas of the skin);
fungal and bacterial infections (however, a pronounced inflammatory process, swelling, itching and pain still require the use of Advantan, but in this case it must be used in conjunction with antimicrobial and antifungalmedicines);
skin manifestations of a reaction to vaccination;
hypersensitivity to the drug.
Also, this tool can not be used for children under four months of age and chronic skin pathology of rosacea.
It is important to know!
Bacterial dermatosis and ringworm in addition to treatment with Advantan require specific antibacterial or antifungal therapy.
It is recommended to avoid getting the drug in the eyes.
As well as the use of systemic corticosteroids, the use of corticosteroids can trigger the development of glaucoma. Contribute to this high doses of medication, prolonged treatment, the use of occlusive dressings, the application of the drug on the skin around the eyes.
Use during pregnancy and lactation
If you need to use the drug "Advantan" in the period of carrying a child or breastfeeding, you should carefully compare the possible risk to the fetus or child and the expected benefits to the mother. The use of the drug in large areas of the skin during these periods is undesirable.
Women who are breastfeeding should not be applied to the mammary glands.
After examining the acute toxicity of methylprednisolone, experts did not reveal any risk of acute intoxication due to excessive single external use (use of the drug over large areas under conditions favorable for absorption) or unintentional ingestion.
Means of similar action
Structural analogues of the active substance does not have the drug "Advantan" (cream). Analogs containing the substance methylprednisolone are as follows:
Terms and conditions of storage
The drug "Advantan" (cream, ointment, emulsion) must be stored at air temperature not higher than 25 ºС, out of the reach of children. The drug is valid for three years from the date of manufacture.
In this article, you learned more information about the drug "Advantan". The drug is highly effective for the treatment of allergic skin diseases, but long-term use of the drug can not be. Be sure to consult with a specialist before using the drug "Advantan" (cream).Analogues of the medication in question should also be used as directed by the doctor. Be healthy!